Subscribe Now
Forgot Password?

Weekly News, Analysis, and Commentary

Large Joints Feature

Source: Wikimedia Commons and Rama

RA Cured in Mice!

Elizabeth Hofheinz, M.P.H., M.Ed. • Fri, August 15th, 2014

Print this article

Swiss researchers at ETH Zurich say that they have treated and cured mice with rheumatoid arthritis (RA). The team indicates that they have developed a drug that is a biotechnologically produced active substance consisting of two fused components. The first one is interleukin 4 (IL-4); then, the ETH scientists “coupled an antibody to IL-4 that, based on the key-lock principle, binds to a form of a protein that is found only in inflamed tissue in certain diseases (and in tumor tissue).”

“As a result of combination with the antibody, IL-4 reaches the site of the disease when the fusion molecule is injected into the body, ” says pharmacist Teresa Hemmerle in the August 6, 2014 news release. Hemmerle has just completed her dissertation in the group of Dario Neri, a professor at the Institute of Pharmaceutical Sciences. Together with Fabia Doll, also a Ph.D. pharmacist at ETH, she is the lead author of the study. “It allows us to concentrate the active substance at the site of the disease. The concentration in the rest of the body is minimal, which reduces side-effects, ” she says.

The researchers found that the mice developed swollen, inflamed toes and paws within a few days. Part of the scientists’ work involved examining “the fusion molecule in combination with dexamethasone, a cortisone-like anti-inflammatory drug that is already used to treat rheumatoid arthritis in humans. The researchers started treating each mouse as soon as they began showing signs of the disease in the form of swollen extremities.”

Administered separately, each medication only managed to slow the progression of the disease in the affected animals. Taken together, however, the drugs resulted in a total halting of the above mentioned symptoms. The team indicated that concentrations of immune messengers in blood and inflamed tissue, which are changed in rheumatoid arthritis, returned to their normal levels. “In our mouse model, this combined treatment creates a long-term cure, ” says Hemmerle, who, since completing her dissertation, has been working at Philochem, where she continues the project.

Philochem will now move forward with clinical trials on people suffering from rheumatoid arthritis.

Send to a Friend

The article link will be sent to the email address you provide

Your Name (required)

Your Email (required)

Friend's Email (required)


One Response to “RA Cured in Mice!”

  1. Sharon says:

    OMG! This is the best news! How many of us know someone who suffers from this aweful disease? How long will it be before this is on the market or before large numbers of people can enroll in a study? Wonderful news!

Leave a Reply


Email Address (will not be published)