Should GLP-1 Be in Your Preop Toolkit—or Not?

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The age of Ozempic isn’t just about shrinking waistlines and skyrocketing stock prices. It’s now knocking on the doors of the OR. A new review article in the July 10, 2025, issue of The Journal of Bone and Joint Surgery dares to ask: Is there a role for GLP-1 receptor agonists (RAs) in orthopedic surgery?

Titled “GLP-1 Receptor Agonists in Orthopaedic Surgery: Implications for Perioperative and Outcomes this paper—authored by Rahul Ramanathan, M.D.; Joon Y. Lee, M.D.; Jonathan F. Dalton, M.D.; and a multidisciplinary crew from Pitt and The Rothman Institute—dives headfirst into one of medicine’s hottest pharmacologic trends.