The room is ready…and then someone clears their throat: “Uh, the patient has a cephalosporin allergy.”
Suddenly, cefazolin — the undisputed MVP of perioperative prophylaxis — is benched in favor of clindamycin or vancomycin. Surgeons all know how this movie ends: higher prosthetic joint infection (PJI) risk, unhappy microbiology, and zero actual allergic reactions prevented.
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