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Revision total knee arthroplasty (TKA) for periprosthetic joint infection (PJI) is already a high-stakes endeavor. You’re managing infection, soft tissue compromise, bone loss, patient comorbidities — and now you’re also expected to perfectly thread the needle (sometimes literally) on venous thromboembolism (VTE) prophylaxis.

For years, many surgeons have defaulted to low-molecular-weight heparin (LMWH) in these complex cases. After all, if the patient is high risk, shouldn’t you go “stronger”?


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