Scientists at the Medical College of Wisconsin, led by Carol Everson, Ph.D., professor of neurology, cell biology, neurobiology and anatomy, have discovered abnormalities in bone and bone marrow in rats undergoing chronic lack of sleep. They found abnormalities in serum markers of bone metabolism in sleep-deprived rats, which led them to conduct direct measurements of bone parameters; this time in rats experiencing recurrent sleep restriction during a large portion of their young adulthood.
The team found a dramatic imbalance between bone apposition and reabsorption, marked by an arrest in bone formation without reduced absorption. Furthermore, fat in the red marrow is greatly diminished and platelet-generating cells are doubled in number, indicating changes to marrow plasticity. “If the same processes are evoked in humans, ” said Dr. Everson in the September 18, 2012 news release, “the potential medical implications are far-reaching and may include poor repair of microdamage from activities of daily living, introduction of osteoporotic processes, and changes to progenitor cells that may affect disease predisposition and disease resistance.”
The researchers observed changes in intramembranous ossification and marrow hypercellularity resulting from chronic sleep loss. “Marrow fat was greatly diminished and reflected increased blood cell production and differentiation. Our findings of increased megakaryocyte numbers, for example, suggest that there is an increased demand for cell delivery to the circulation consistent with an inflammatory response, and conceivably the promotion of thrombocytosis, ” said Dr. Everson.
Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said, “With increased life stress due to work-related, financial and other issues a large percentage of us are experiencing difficulties in sleeping. While we know that chronic sleep loss can affect our health little specific information has been available on how it may impact bone formation or loss. Drs. Everson and Toth, together with Anne Folley present exciting results indicating that sleep deprivation in rats arrests new bone formation, decreases fat within the red marrow and increases platelet levels. If true in humans, and I expect that it may be, this work will have great impact on our understanding of the impact of sleep deprivation on osteoporosis and inability to repair bone damage as we age.”
Dr. Everson told OTW,
I was surprised to learn that sleep loss would arrest bone apposition and change the cellular make-up of the bone marrow. If these changes occur in sleep deficient humans, key aspects of development, repair, and recuperation would be affected. The findings on chronic sleep loss point to specific alterations in cellular and structural mechanisms that affect growth and repair. Orthopedic surgeons should be aware that sleep deficiency may be an important risk factor for abnormal bone health that could affect healing.
